Article
Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.
Diabetes - 1 May 2012
Smushkin Galina, Sathananthan Matheni, Sathananthan Airani, Dalla Man Chiara, Micheletto Francesco, Zinsmeister Alan R, Cobelli Claudio, Vella Adrian
Abstract excerpt
The mechanisms by which common genetic variation predisposes to type 2 diabetes remain unclear. The disease-associated variants in TCF7L2 (rs7903146) and WFS1 (rs10010131) have been shown to affect response to exogenous glucagon-like peptide 1 (GLP-1), while variants in KCNQ1 (rs151290, rs2237892, and rs2237895) alter endogenous GLP-1 secretion. We set out to validate these observations using a model of...