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The effects of DNA double-strand breaks on mouse oocyte meiotic maturation

12 Apr 2013

Abstract excerpt

Both endogenous and exogenous factors can induce DNA double-strand breaks (DSBs) in oocytes, which is a potential risk for human-assisted reproductive technology as well as animal nuclear transfer. Here we used bleomycin (BLM) and laser micro-beam dissection (LMD) to induce DNA DSBs in germinal vesicle (GV) stage oocytes and compared the germinal vesicle breakdown (GVBD) rates and first polar body extrusion (PBE)...

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PMID: 23518501
DOI: 10.4161/cc.24311

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