Article
Enhanced Ca2+ transport and muscle relaxation in skeletal muscle from sarcolipin-null mice.
American journal of physiology. Cell physiology - 1 Oct 2011
Tupling A Russell, Bombardier Eric, Gupta Subash C, Hussain Dawar, Vigna Chris, Bloemberg Darin, Quadrilatero Joe, Trivieri Maria G, Babu Gopal J, Backx Peter H, Periasamy Muthu, MacLennan David H, Gramolini Anthony O
Abstract excerpt
Sarcolipin (SLN) inhibits sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) pumps. To evaluate the physiological significance of SLN in skeletal muscle, we compared muscle contractility and SERCA activity between Sln-null and wild-type mice. SLN protein expression in wild-type mice was abundant in soleus and red gastrocnemius (RG), low in extensor digitorum longus (EDL), and absent from white gastrocnemius (WG)....
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