Article
Genetic variations in the homologous recombination repair pathway genes modify risk of glioma.
Journal of neuro-oncology - 1 Jan 2016
Zhang Haishi, Liu Yanhong, Zhou Keke, Zhou Chengcheng, Zhou Renke, Cheng Chunxia, Wei Qingyi, Lu Daru, Zhou Liangfu
Abstract excerpt
Accumulative epidemiological evidence suggests that single nucleotide polymorphisms (SNPs) in genes involved in homologous recombination (HR) DNA repair pathway play an important role in glioma susceptibility. However, the effects of such SNPs on glioma risk remain unclear. We used a used a candidate pathway-based approach to elucidate the relationship between glioma risk and 12 putative functional SNPs in genes...
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