Article
Polymorphisms of LIG4 and XRCC4 involved in the NHEJ pathway interact to modify risk of glioma.
Human mutation - 1 Mar 2008
Liu Yanhong, Zhou Keke, Zhang Haishi, Shugart Yin Yao, Chen Lina, Xu Zhonghui, Zhong Yu, Liu Hongliang, Jin Li, Wei Qingyi, Huang Fengping, Lu Daru, Zhou Liangfu
Abstract excerpt
Although the role of environmental risk factors in the etiology of gliomas remains to be elucidated, accumulative epidemiological evidence suggests that genetic factors, such as variants in genes involved in DNA repair, may also play an important role. LIG4 and XRCC4 are known to form a complex and are functionally linked in the repair of double-stranded DNA breaks. To determine whether LIG4 and XRCC4...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.