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Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain

29 Oct 2015

Abstract excerpt

UNLABELLED: HIV-1 uses cellular machinery to bud from infected cells. This cellular machinery is comprised of several multiprotein complexes known as endosomal sorting complexes required for transport (ESCRTs). A conserved late domain motif, Pro-Thr-Ala-Pro (PTAP), located in the p6 region of Gag (p6(Gag)), plays a central role in ESCRT recruitment to the site of virus budding. Previous studies have demonstrated...

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PMID: 26512081
DOI: 10.1128/jvi.01640-15

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