Article
The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility.
Retrovirology - 6 Sept 2016
Watanabe Susan M, Simon Viviana, Durham Natasha D, Kemp Brittney R, Machihara Satoshi, Kemal Kimdar Sherefa, Shi Binshan, Foley Brian, Li Hongru, Chen Benjamin K, Weiser Barbara, Burger Harold, Anastos Kathryn, Chen Chaoping, Carter Carol A
Abstract excerpt
BACKGROUND: The p6 region of the HIV-1 structural precursor polyprotein, Gag, contains two motifs, P7TAP11 and L35YPLXSL41, designated as late (L) domain-1 and -2, respectively. These motifs bind the ESCRT-I factor Tsg101 and the ESCRT adaptor Alix, respectively, and are critical for efficient budding of virus particles from the plasma membrane. L domain-2 is thought to be functionally redundant to PTAP. To...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.