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Article

Functional organization of an Mbp enhancer exposes striking transcriptional regulatory diversity within myelinating glia.

Glia - 1 Jan 2016

Dionne Nancy, Dib Samar, Finsen Bente, Denarier Eric, Kuhlmann Tanja, Drouin Régen, Kokoeva Maia, Hudson Thomas J, Siminovitch Kathy, Friedman Hana C, Peterson Alan C

Abstract excerpt

In mammals, large caliber axons are ensheathed by myelin, a glial specialization supporting axon integrity and conferring accelerated and energy-efficient action potential conduction. Myelin basic protein (MBP) is required for normal myelin elaboration with maximal mbp transcription in oligodendrocytes requiring the upstream M3 enhancer. To further characterize the mechanism regulating mbp transcription, we...

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Identifiers

PMID: 26507463
DOI: 10.1002/glia.22923

Genes

MBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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