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Article

From sites to structure to serology: a roadmap for structure-aware molecular evolution of antigenically evolving viruses.

Journal of virology - 18 Aug 2026

Översti Sanni, Lytras Spyros, Kawakubo Shusuke, Ito Jumpei, Ghafari Mahan

Abstract excerpt

The genomic deluge has pushed viral molecular evolution into a site-resolved era. For antigenically evolving viruses such as influenza and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), dense genomic sampling now supports mutation-annotated phylogenies and per-site estimates of mutation and substitution processes. These data highlight strong effects of sequence context, genomic region, RNA...

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Identifiers

PMID: 42461048
DOI: 10.1128/jvi.01687-25
PMCID: PMC13483445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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