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Article

p120-catenin prevents multinucleation through control of MKLP1-dependent RhoA activity during cytokinesis

22 Dec 2016

Abstract excerpt

Spatiotemporal activation of RhoA and actomyosin contraction underpins cellular adhesion and division. Loss of cell-cell adhesion and chromosomal instability are cardinal events that drive tumour progression. Here, we show that p120-catenin (p120) not only controls cell-cell adhesion, but also acts as a critical regulator of cytokinesis. We find that p120 regulates actomyosin contractility through concomitant...

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PMID: 28004812
DOI: 10.1038/ncomms13874

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