Article
Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis.
The EMBO journal - 30 May 2012
Makyio Hisayoshi, Ohgi Minako, Takei Tomomi, Takahashi Senye, Takatsu Hiroyuki, Katoh Yohei, Hanai Ayako, Ueda Tomoko, Kanaho Yasunori, Xie Yong, Shin Hye-Won, Kamikubo Hironari, Kataoka Mikio, Kawasaki Masato, Kato Ryuichi, Wakatsuki Soichi, Nakayama Kazuhisa
Abstract excerpt
A small GTPase, Arf6, is involved in cytokinesis by localizing to the Flemming body (the midbody). However, it remains unknown how Arf6 contributes to cytokinesis. Here, we demonstrate that Arf6 directly interacts with mitotic kinesin-like protein 1 (MKLP1), a Flemming body-localizing protein essential for cytokinesis. The crystal structure of the Arf6-MKLP1 complex reveals that MKLP1 forms a homodimer flanked by...
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