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Article

RABGTPases in MT1-MMP trafficking and cell invasion: Physiology versus pathology

24 Jun 2015

Abstract excerpt

The matrix metalloproteinase MT1-MMP is a central regulator of cell invasion in both physiological and pathological settings, such as tissue surveillance by immune cells and cancer cell metastasis. MT1-MMP cleaves a plethora of intra- and extracellular proteins, including extracellular matrix proteins, matrix receptors, and also other MMPs, and thus enables modification of both the cell surface proteome and the...

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PMID: 26107110
DOI: 10.4161/21541248.2014.985484

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