Article
Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma.
Scientific reports - 27 Oct 2015
Li Chenguang, Gao Zhibo, Li Fei, Li Xiangchun, Sun Yihua, Wang Mengyun, Li Dan, Wang Rui, Li Fuming, Fang Rong, Pan Yunjian, Luo Xiaoyang, He Jing, Zheng Liangtao, Xia Jufeng, Qiu Lixin, He Jun, Ye Ting, Zhang Ruoxin, He Minghui, Zhu Meiling, Hu Haichuan, Shi Tingyan, Zhou Xiaoyan, Sun Menghong, Tian Shilin, Zhou Yong, Wang Qiaoxiu, Chen Longyun, Yin Guangliang, Lu Jingya, Wu Renhua, Guo Guangwu, Li Yingrui, Hu Xueda, Li Lin, Asan, Wang Qin, Yin Ye, Feng Qiang, Wang Bin, Wang Hang, Wang Mingbang, Yang Xiaonan, Zhang Xiuqing, Yang Huanming, Jin Li, Wang Cun-Yu, Ji Hongbin, Chen Haiquan, Wang Jun, Wei Qingyi
Abstract excerpt
Lung squamous cell carcinoma (SQCC) accounts for about 30% of all lung cancer cases. Understanding of mutational landscape for this subtype of lung cancer in Chinese patients is currently limited. We performed whole exome sequencing in samples from 100 patients with lung SQCCs to search for somatic mutations and the subsequent target capture sequencing in another 98 samples for validation. We identified 20...
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