Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer.

doi:10.1371/journal.pgen.1005895

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Article

Genomic Landscape Survey Identifies SRSF1 as a Key Oncodriver in Small Cell Lung Cancer.

PLoS genetics - 1 Apr 2016

Jiang Liyan, Huang Jiaqi, Higgs Brandon W, Hu Zhibin, Xiao Zhan, Yao Xin, Conley Sarah, Zhong Haihong, Liu Zheng, Brohawn Philip, Shen Dong, Wu Song, Ge Xiaoxiao, Jiang Yue, Zhao Yizhuo, Lou Yuqing, Morehouse Chris, Zhu Wei, Sebastian Yinong, Czapiga Meggan, Oganesyan Vaheh, Fu Haihua, Niu Yanjie, Zhang Wei, Streicher Katie, Tice David, Zhao Heng, Zhu Meng, Xu Lin, Herbst Ronald, Su Xinying, Gu Yi, Li Shyoung, Huang Lihua, Gu Jianren, Han Baohui, Jallal Bahija, Shen Hongbing, Yao Yihong

Abstract excerpt

Small cell lung cancer (SCLC) is an aggressive disease with poor survival. A few sequencing studies performed on limited number of samples have revealed potential disease-driving genes in SCLC, however, much still remains unknown, particularly in the Asian patient population. Here we conducted whole exome sequencing (WES) and transcriptomic sequencing of primary tumors from 99 Chinese SCLC patients. Dysregulation...

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Identifiers

PMID: 27093186
DOI: 10.1371/journal.pgen.1005895
PMCID: PMC4836692

Genes

SRSF1

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