Article
Whole-exome sequencing to identify novel somatic mutations in squamous cell lung cancers.
International journal of oncology - 1 Sept 2013
Zheng Cui-Xia, Gu Zhao-Hui, Han Bing, Zhang Rong-Xin, Pan Chun-Ming, Xiang Yi, Rong Xia-Jun, Chen Xia, Li Qing-Yun, Wan Huan-Ying
Abstract excerpt
Squamous cell lung cancer is a major histotype of non-small cell lung cancer (NSCLC) that is distinct from lung adenocarcinoma. We used whole-exome sequencing to identify novel non-synonymous somatic mutations in squamous cell lung cancer. We identified 101 single-nucleotide variants (SNVs) including 77 non-synonymous SNVs (67 missense and 10 nonsense mutations) and 11 INDELs causing frameshifts. We also found...
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