Article
Identification of somatic mutations in non-small cell lung carcinomas using whole-exome sequencing.
Carcinogenesis - 1 Jul 2012
Liu Pengyuan, Morrison Carl, Wang Liang, Xiong Donghai, Vedell Peter, Cui Peng, Hua Xing, Ding Feng, Lu Yan, James Michael, Ebben John D, Xu Haiming, Adjei Alex A, Head Karen, Andrae Jaime W, Tschannen Michael R, Jacob Howard, Pan Jing, Zhang Qi, Van den Bergh Francoise, Xiao Haijie, Lo Ken C, Patel Jigar, Richmond Todd, Watt Mary-Anne, Albert Thomas, Selzer Rebecca, Anderson Marshall, Wang Jiang, Wang Yian, Starnes Sandra, Yang Ping, You Ming
Abstract excerpt
Lung cancer is the leading cause of cancer-related death, with non-small cell lung cancer (NSCLC) being the predominant form of the disease. Most lung cancer is caused by the accumulation of genomic alterations due to tobacco exposure. To uncover its mutational landscape, we performed whole-exome sequencing in 31 NSCLCs and their matched normal tissue samples. We identified both common and unique mutation spectra...
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