Article

Efficient gene disruption with CRISPR-Cas3 in human T cells

2025-08-08

Abstract excerpt

<h4>Summary</h4> The CRISPR-Cas9 system has been widely adopted as a genome editing tool due to its high efficiency and versatility, contributing to the development of various therapeutic strategies. However, its clinical application remains limited by safety concerns, including off-target effects and large-scale chromosomal rearrangements such as translocations and inversions. Recently, the CRISPR-Cas3 system, a...

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Literature Corpus work: 0ec08991-d86b-5aec-b8b1-05e2f7562461
DOI: 10.1101/2025.08.06.668737

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