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The clinical potential of gene editing as a tool to engineer cell‐based therapeutics

1 Jan 2020

Abstract excerpt

T-cells. Editing aimed to disrupt expression of the human immunodeficiency virus co-receptor gene CCR5, with the goal of yielding cells resistant to viral entry, prior to re-infusion into the patient. Since then the field has substantially evolved with the arrival of the new editing technologies transcription activator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeats...

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PMID: 32034584
DOI: 10.1186/s40169-020-0268-z

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