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Article

Association of TLR2 S450S and ICAM1 K469E polymorphisms with polycystic ovary syndrome (PCOS) and obesity.

Journal of reproductive immunology - 1 Feb 2016

Ojeda-Ojeda Miriam, Martínez-García M Ángeles, Alpañés Macarena, Luque-Ramírez Manuel, Escobar-Morreale Héctor F

Abstract excerpt

Toll-like receptors (TLRs) are activated by inflammatory stimuli and influence endothelial functions, contributing to the pathogenesis of atherosclerosis. We investigate the influence of polymorphisms in the genes encoding toll-like receptor 2 (TLR2) and 4 (TLR4) and endothelial adhesion molecules on polycystic ovary syndrome (PCOS) and its interaction with obesity. Ten single nucleotide polymorphisms were...

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Source

Identifiers

PMID: 26498675
DOI: 10.1016/j.jri.2015.09.072

Genes

TLR2
ICAM1
TLR4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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