The role of chronic inflammation and Leu55Met PON1 polymorphism in the pathogenesis of polycystic ovary syndrome.

doi:10.3109/09513591003686387

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Article

The role of chronic inflammation and Leu55Met PON1 polymorphism in the pathogenesis of polycystic ovary syndrome.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology - 1 Sept 2010

Lenarcik Agnieszka, Bidzińska-Speichert Bozena, Tworowska-Bardzińska Urszula

Abstract excerpt

INTRODUCTION: Polycystic ovary syndrome (PCOS) is an endocrine disorder with a complex pathogenesis in which hormonal disturbances, metabolic disorders and chronic inflammation have been considered. Relationships among the paraoxonase 1 (PON1) gene, hyperandrogenism and insulin resistance in women with PCOS have been reported. AIM: The aim of this study was to evaluate patients with PCOS for the existence of...

Topics

Adult
Amino Acid Substitution
Aryldialkylphosphatase
Case-Control Studies
Chronic Disease
Female
Glucose Tolerance Test
Humans
Inflammation
Insulin Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Leucine

Methionine

Polycystic Ovary Syndrome

Polymorphism, Single Nucleotide

Testosterone

Young Adult

Source

Open in PubMed

Identifiers

PMID: 20334584
DOI: 10.3109/09513591003686387

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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