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Article

Whole exome sequencing of microdissected splenic marginal zone lymphoma: a study to discover novel tumor-specific mutations.

BMC cancer - 24 Oct 2015

Peveling-Oberhag Jan, Wolters Franziska, Döring Claudia, Walter Dirk, Sellmann Ludger, Scholtysik René, Lucioni Marco, Schubach Max, Paulli Marco, Biskup Saskia, Zeuzem Stefan, Küppers Ralf, Hansmann Martin-Leo

Abstract excerpt

BACKGROUND: Splenic marginal zone lymphoma (SMZL) is an indolent B-cell non-Hodgkin lymphoma and represents the most common primary malignancy of the spleen. Its precise molecular pathogenesis is still unknown and specific molecular markers for diagnosis or possible targets for causal therapies are lacking. METHODS: We performed whole exome sequencing (WES) and copy number analysis from laser-microdissected tumor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26498442
DOI: 10.1186/s12885-015-1766-z
PMCID: PMC4619476

Genes

NOTCH2
MYD88
SMYD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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