Article
Immunogenetics features and genomic lesions in splenic marginal zone lymphoma.
British journal of haematology - 1 Dec 2010
Rinaldi Andrea, Forconi Francesco, Arcaini Luca, Mian Michael, Sozzi Elena, Zibellini Silvia, Baldini Luca, Franceschetti Silvia, Gaidano Gianluca, Marasca Roberto, Mollejo Manuela, Piris Miguel A, Tucci Alessandra, Facchetti Fabio, Bhagat Govind, Favera Riccardo D, Rancoita Paola M V, Zucca Emanuele, Kwee Ivo, Bertoni Francesco
Abstract excerpt
Splenic marginal zone lymphomas (MZL) express mutated (M)) or unmutated (U)) immunoglobulin heavy chain (IGHV) genes. To investigate the IGHV mutational status impact on genetic lesions, this study combined single nucleotide polymorphism-arrays and IGHV sequencing in 83 cases. Clinical features and outcome were similar between U- and M-IGHV cases. Recurrent lesions frequency was higher in U-IGHV cases, including...
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