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Article

Structural analysis of Fc/FcγR complexes: a blueprint for antibody design.

Immunological reviews - 1 Nov 2015

Caaveiro Jose M M, Kiyoshi Masato, Tsumoto Kouhei

Abstract excerpt

The number of studies and the quality of the structural data of Fcγ receptors (FcγRs) has rapidly increased in the last few years. Upon critical examination of the literature, we have extracted general conclusions that could explain differences in affinity and selectivity of FcγRs for immunoglobulin G (IgG) based on structural considerations. FcγRs employ a little conserved asymmetric surface of domain D2...

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Share to Antibody Affinity
Share to Glycosylation
Share to Immunoglobulin Fc Fragments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Interaction Domains and Motifs

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Source

Identifiers

PMID: 26497522
DOI: 10.1111/imr.12365

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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