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Article

Structural characterization of anti-inflammatory immunoglobulin G Fc proteins.

Journal of molecular biology - 9 Sept 2014

Ahmed Alysia A, Giddens John, Pincetic Andrew, Lomino Joseph V, Ravetch Jeffrey V, Wang Lai-Xi, Bjorkman Pamela J

Abstract excerpt

Immunoglobulin G (IgG) is a central mediator of host defense due to its ability to recognize and eliminate pathogens. The recognition and effector responses are encoded on distinct regions of IgGs. The diversity of the antigen recognition Fab domains accounts for IgG's ability to bind with high specificity to essentially any antigen. Recent studies have indicated that the Fc effector domain also displays...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25036289
DOI: 10.1016/j.jmb.2014.07.006
PMCID: PMC4159253

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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