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Article

Novel transcript truncating function of Rap1p revealed by synthetic codon-optimized Ty1 retrotransposon.

Genetics - 1 Feb 2012

Yarrington Robert M, Richardson Sarah M, Lisa Huang Cheng Ran, Boeke Jef D

Abstract excerpt

Extensive mutagenesis via massive recoding of retrotransposon Ty1 produced a synthetic codon-optimized retrotransposon (CO-Ty1). CO-Ty1 is defective for retrotransposition, suggesting a sequence capable of down-regulating retrotransposition. We mapped this sequence to a critical ~20-bp region within CO-Ty1 reverse transcriptase (RT) and confirmed that it reduced Ty1 transposition, protein, and RNA levels....

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Identifiers

PMID: 22135353
DOI: 10.1534/genetics.111.136648
PMCID: PMC3276619

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Source receipt: pubmed, retrieved 7 Sept 2026.

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