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Article

Overshoot during phenotypic switching of cancer cell populations.

Scientific reports - 23 Oct 2015

Sellerio Alessandro L, Ciusani Emilio, Ben-Moshe Noa Bossel, Coco Stefania, Piccinini Andrea, Myers Christopher R, Sethna James P, Giampietro Costanza, Zapperi Stefano, La Porta Caterina A M

Abstract excerpt

The dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a subpopulation of cancer stem cells (CSCs), or are stochastic transitions that mutate differentiated cancer cells to CSCs important? Here we argue that regulation must also be important. We sort human melanoma cells using three distinct cancer stem cell (CSC) markers - CXCR6, CD271 and ABCG2 - and observe that the...

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Identifiers

PMID: 26494317
DOI: 10.1038/srep15464
PMCID: PMC4616026

Genes

ABCG2
CXCR6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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