Article
Mechanisms of action of ribavirin against distinct viruses.
Reviews in medical virology - 1 Jan 2000
Graci Jason D, Cameron Craig E
Abstract excerpt
The nucleoside analogue ribavirin has antiviral activity against many distinct viruses both in vitro and in vivo. Five distinct mechanisms have been proposed to explain the antiviral properties of ribavirin. These include both indirect mechanisms (inosine monophosphate dehydrogenase inhibition, immunomodulatory effects) and direct mechanisms (interference with RNA capping, polymerase inhibition, lethal...
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