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Article

Generation and characterization of influenza A viruses with altered polymerase fidelity.

Nature communications - 3 Sept 2014

Cheung Peter P H, Watson Simon J, Choy Ka-Tim, Fun Sia Sin, Wong Diana D Y, Poon Leo L M, Kellam Paul, Guan Yi, Malik Peiris J S, Yen Hui-Ling

Abstract excerpt

Genetic diversity of influenza A viruses (IAV) acquired through the error-prone RNA-dependent RNA polymerase (RdRP) or through genetic reassortment enables perpetuation of IAV in humans through epidemics or pandemics. Here, to assess the biological significance of genetic diversity acquired through RdRP, we characterize an IAV fidelity variant derived from passaging a seasonal H3N2 virus in the presence of...

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Source

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Identifiers

PMID: 25183443
DOI: 10.1038/ncomms5794
PMCID: PMC4155405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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