Article
RNA virus error catastrophe: direct molecular test by using ribavirin.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2001
Crotty S, Cameron C E, Andino R
Abstract excerpt
RNA viruses evolve rapidly. One source of this ability to rapidly change is the apparently high mutation frequency in RNA virus populations. A high mutation frequency is a central tenet of the quasispecies theory. A corollary of the quasispecies theory postulates that, given their high mutation frequency, animal RNA viruses may be susceptible to error catastrophe, where they undergo a sharp drop in viability...
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