Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KIR haplotypes are associated with late-onset type 1 diabetes in European-American families.

Genes and immunity - 1 Jan 2000

Traherne J A, Jiang W, Valdes A M, Hollenbach J A, Jayaraman J, Lane J A, Johnson C, Trowsdale J, Noble J A

Abstract excerpt

Classical human leukocyte antigens (HLA) genes confer the strongest, but not the only, genetic susceptibility to type 1 diabetes. Killer cell immunoglobulin-like receptors (KIR), on natural killer (NK) cells, bind ligands including class I HLA. We examined presence or absence, with copy number, of KIR loci in 1698 individuals, from 339 multiplex type 1 diabetes families, from the Human Biological Data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Child
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Haplotypes

Share to HLA Antigens

Share to Receptors, KIR

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 26492518
DOI: 10.1038/gene.2015.44
PMCID: PMC4746488

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KIR haplotypes are associated with late-onset type 1 diabetes in European-American families.PMID 26492518Read ↗

Association of Killer Cell Immunoglobulin-Like Receptors and Their HLA-Ligands with Type 1 Diabetes Among South Indian Population.Semantic proximity Read ↗

Next-generation sequencing reveals additional HLA class I and class II alleles associated with type 1 diabetes and age at onset.Semantic proximity Read ↗

KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects.Semantic proximity Read ↗

Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.Semantic proximity Read ↗

Genetic discovery and risk prediction for type 1 diabetes in individuals without high-risk HLA-DR3/DR4 haplotypesSemantic proximity Read ↗

Defining KIR and HLA Class I Genotypes at Highest Resolution via High-Throughput Sequencing.Semantic proximity Read ↗

Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 DiabetesSemantic proximity Read ↗

Inhibitory KIRs decrease HLA class II-mediated protection in Type 1 Diabetes.Semantic proximity Read ↗

Allele-level haplotype frequencies and pairwise linkage disequilibrium for 14 KIR loci in 506 European-American individuals.Semantic proximity Read ↗

Fifty years of HLA-associated type 1 diabetes risk: history, current knowledge, and future directions.Semantic proximity Read ↗

Complete HLA genotyping of type 1 diabetes patients and controls from Mali reveals both expected and novel disease associations.Semantic proximity Read ↗

Haplotype-Based Analysis of KIR-Gene Profiles in a South European Population-Distribution of Standard and Variant Haplotypes, and Identification of Novel Recombinant Structures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.