Article
Association of Killer Cell Immunoglobulin-Like Receptors and Their HLA-Ligands with Type 1 Diabetes Among South Indian Population.
Immunological investigations - 1 Apr 2023
Gunavathy Nagarajan, Asirvatham Arthur, Chitra Ayyappan, Jayalakshmi Mariakuttikan
Abstract excerpt
BACKGROUND: Type 1 diabetes (T1D) is a multifactorial autoimmune disease, involving strong genetic components with familial predisposition. Killer cell immunoglobulin-like receptors (KIRs) found on the surface of NK cells have ligands of human leukocyte antigen (HLA) class I that are associated with T1D. The present study evaluates the influence of KIR genes and their HLA-ligands in the aetiology of T1D among the...
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