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Article

A limited sampling strategy based on maximum a posteriori Bayesian estimation for a five-probe phenotyping cocktail.

European journal of clinical pharmacology - 1 Jan 2016

Nguyen Thu Thuy, Bénech Henri, Pruvost Alain, Lenuzza Natacha

Abstract excerpt

PURPOSE: Cocktail approach using a combination of probes to phenotype several cytochromes P450 or transporters is of high interest in anticipating drug–drug interactions and personalized medicine. Its clinical use remains however limited by the intensive sampling scheme required to obtain phenotyping indexes (PI) which consists in calculating the area under the concentration–time curves. We proposed to use...

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PMID: 26490357
DOI: 10.1007/s00228-015-1953-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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