Article
Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.
Immunity - 20 Oct 2015
Cao Zhifang, Conway Kara L, Heath Robert J, Rush Jason S, Leshchiner Elizaveta S, Ramirez-Ortiz Zaida G, Nedelsky Natalia B, Huang Hailiang, Ng Aylwin, Gardet Agnès, Cheng Shih-Chin, Shamji Alykhan F, Rioux John D, Wijmenga Cisca, Netea Mihai G, Means Terry K, Daly Mark J, Xavier Ramnik J
Abstract excerpt
CARD9 is a central component of anti-fungal innate immune signaling via C-type lectin receptors, and several immune-related disorders are associated with CARD9 alterations. Here, we used a rare CARD9 variant that confers protection against inflammatory bowel disease as an entry point to investigating CARD9 regulation. We showed that the protective variant of CARD9, which is C-terminally truncated, acted in a...
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