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Translational genetics identifies a phosphorylation switch in CARD9 required for innate inflammatory responses

1 Mar 2024

Abstract excerpt

Population genetics continues to identify genetic variants associated with diseases of the immune system and offers a unique opportunity to discover mechanisms of immune regulation. Multiple genetic variants linked to severe fungal infections and autoimmunity are associated with caspase recruitment domain-containing protein 9 (CARD9). We leverage the CARD9 R101C missense variant to uncover a biochemical mechanism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38489265
DOI: 10.1016/j.celrep.2024.113944

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