Article
CARD9 Signaling in Intestinal Immune Homeostasis and Oncogenesis
8 Mar 2019
Abstract excerpt
Intestinal homeostasis requires a balanced interaction between the host innate immune system and the gut microbiota. A dysregulation of this interdependency can result in inflammatory bowel diseases (IBDs), and this dysregulation is a key pathogenic factor during the development of colorectal cancer. CARD9 is a central signalling molecule in the innate immune system, which is essential for host defence against...
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