Article
Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease.
Proceedings of the National Academy of Sciences of the United States of America - 24 Oct 2017
Leshchiner Elizaveta S, Rush Jason S, Durney Michael A, Cao Zhifang, Dančík Vlado, Chittick Benjamin, Wu Huixian, Petrone Adam, Bittker Joshua A, Phillips Andrew, Perez Jose R, Shamji Alykhan F, Kaushik Virendar K, Daly Mark J, Graham Daniel B, Schreiber Stuart L, Xavier Ramnik J
Abstract excerpt
Advances in human genetics have dramatically expanded our understanding of complex heritable diseases. Genome-wide association studies have identified an allelic series of CARD9 variants associated with increased risk of or protection from inflammatory bowel disease (IBD). The predisposing variant of CARD9 is associated with increased NF-κB-mediated cytokine production. Conversely, the protective variant lacks a...
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