Article
Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.
Journal of atherosclerosis and thrombosis - 27 Oct 2010
Koriyama Hiroshi, Nakagami Hironori, Katsuya Tomohiro, Sugimoto Ken, Yamashita Hidetoshi, Takami Yoichi, Maeda Shiro, Kubo Michiaki, Takahashi Atsushi, Nakamura Yusuke, Ogihara Toshio, Rakugi Hiromi, Kaneda Yasufumi, Morishita Ryuichi
Abstract excerpt
AIM: Peripheral arterial disease (PAD) is a common cause of cardiovascular morbidity and an independent predictor of cardiovascular mortality. However, little is known about the genetic basis of PAD. To elucidate this, we performed a two-staged genome-wide association study in Japanese individuals. METHODS: We initially tested 222,285 single-nucleotide polymorphisms (SNPs). After the first screening in a panel of...
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