Population genomics of Mycobacterium tuberculosis in the Inuit.

doi:10.1073/pnas.1507071112

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Article

Population genomics of Mycobacterium tuberculosis in the Inuit.

Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2015

Lee Robyn S, Radomski Nicolas, Proulx Jean-Francois, Levade Ines, Shapiro B Jesse, McIntosh Fiona, Soualhine Hafid, Menzies Dick, Behr Marcel A

Abstract excerpt

Nunavik, Québec suffers from epidemic tuberculosis (TB), with an incidence 50-fold higher than the Canadian average. Molecular studies in this region have documented limited bacterial genetic diversity among Mycobacterium tuberculosis isolates, consistent with a founder strain and/or ongoing spread. We have used whole-genome sequencing on 163 M. tuberculosis isolates from 11 geographically isolated villages to...

Topics

Genes, Bacterial
Genetics, Population
Humans
Inuit
Mycobacterium tuberculosis
Polymorphism, Single Nucleotide
Quebec
Selection, Genetic
Tuberculosis

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Identifiers

PMID: 26483462
DOI: 10.1073/pnas.1507071112
PMCID: PMC4640744

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