Article
Bacterial genetic signatures of human social phenomena among M. tuberculosis from an Aboriginal Canadian population.
Molecular biology and evolution - 1 Feb 2010
Pepperell Caitlin, Hoeppner Vernon H, Lipatov Mikhail, Wobeser Wendy, Schoolnik Gary K, Feldman Marcus W
Abstract excerpt
Despite a widespread global distribution and highly variable disease phenotype, there is little DNA sequence diversity among isolates of Mycobacterium tuberculosis. In addition, many regional population genetic surveys have revealed a stereotypical structure in which a single clone, lineage, or clade makes up the majority of the population. It is often assumed that dominant clones are highly adapted, that is, the...
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