Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Previously undetected super-spreading of Mycobacterium tuberculosis revealed by deep sequencing.

eLife - 4 Feb 2020

Lee Robyn S, Proulx Jean-François, McIntosh Fiona, Behr Marcel A, Hanage William P

Abstract excerpt

Tuberculosis disproportionately affects the Canadian Inuit. To address this, it is imperative we understand transmission dynamics in this population. We investigate whether 'deep' sequencing can provide additional resolution compared to standard sequencing, using a well-characterized outbreak from the Arctic (2011-2012, 50 cases). Samples were sequenced to ~500-1000x and reads were aligned to a novel local...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier State
Share to Disease Outbreaks
Share to Genome, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Molecular Epidemiology

Share to Mycobacterium tuberculosis

Share to Polymorphism, Single Nucleotide

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 32014110
DOI: 10.7554/eLife.53245
PMCID: PMC7012596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Previously undetected super-spreading of Mycobacterium tuberculosis revealed by deep sequencing.PMID 32014110Read ↗

Reemergence and amplification of tuberculosis in the Canadian arctic.Semantic proximity Read ↗

Molecular Epidemiology of Mycobacterium tuberculosis To Describe the Transmission Dynamics Among Inuit Residing in Iqaluit Nunavut Using Whole-Genome Sequencing.Semantic proximity Read ↗

Population genomics of Mycobacterium tuberculosis in the Inuit.Semantic proximity Read ↗

Tuberculosis super-spreading due to interterritorial mobility and prolonged diagnostic delay: A call for an integrated and enhanced analysisSemantic proximity Read ↗

Identifying Likely Transmission Pathways within a 10-Year Community Outbreak of Tuberculosis by High-Depth Whole Genome Sequencing.Semantic proximity Read ↗

Interpreting whole genome sequencing for investigating tuberculosis transmission: a systematic review.Semantic proximity Read ↗

Direct nanopore sequencing of <i>M. tuberculosis</i> on sputa and rescue of suboptimal results to enhance transmission surveillanceSemantic proximity Read ↗

How much do smear-negative patients really contribute to tuberculosis transmissions? Re-examining an old question with new toolsSemantic proximity Read ↗

The use of mycobacterial interspersed repetitive unit typing and whole genome sequencing to inform tuberculosis prevention and control activities.Semantic proximity Read ↗

Mycobacterium tuberculosis and whole-genome sequencing: how close are we to unleashing its full potential?Semantic proximity Read ↗

Direct transmission of within-host Mycobacterium tuberculosis diversity to secondary cases can lead to variable between-host heterogeneity without de novo mutation: A genomic investigationSemantic proximity Read ↗

Tuberculosis in the Inuit Community of Quebec, CanadaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.