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Article

Neurobiological basis of bipolar disorder: Mitochondrial dysfunction hypothesis and beyond

10 Nov 2016

Abstract excerpt

Bipolar disorder is one of two major psychotic disorders together with schizophrenia and causes severe psychosocial disturbance. Lack of adequate animal models hampers development of new mood stabilizers. We proposed a mitochondrial dysfunction hypothesis and have been studying the neurobiology of bipolar disorder based on this hypothesis. We showed that deletions of mitochondrial DNA (ΔmtDNA) play a...

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PMID: 27839913
DOI: 10.1016/j.schres.2016.10.037

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