Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Behavioral profile in a Dctn1G71A knock-in mouse model of Perry disease.

Neuroscience letters - 1 Nov 2021

Deshimaru Manami, Mishima Takayasu, Watanabe Takuya, Kubota Kaori, Hosoi Mana, Kinoshita-Kawada Mariko, Yuasa-Kawada Junichi, Ikeda Maiko, Mori Masayoshi, Murata Yusuke, Abe Takaya, Enjoji Munechika, Kiyonari Hiroshi, Kodama Shohta, Fujioka Shinsuke, Iwasaki Katsunori, Tsuboi Yoshio

Abstract excerpt

Perry disease (Perry syndrome) is a rare, rapidly progressive, autosomal dominant neurodegenerative disease characterized by parkinsonism, depression/apathy, weight loss, and respiratory symptoms including central hypoventilation. It is caused by missense mutations (e.g. p.G71A) in the DCTN1 gene. We previously generated transgenic mice that expressed human DCTN1G71A mutant protein under the control of Thy1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Depression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dynactin Complex

Share to Gene Knock-In Techniques

Share to Hypoventilation

Share to Parkinsonian Disorders

Share to Substantia Nigra

Share to Tyrosine 3-Monooxygenase

Source

Identifiers

PMID: 34508845
DOI: 10.1016/j.neulet.2021.136234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Behavioral profile in a Dctn1G71A knock-in mouse model of Perry disease.PMID 34508845Read ↗

Behavioral defects in a DCTN1G71A transgenic mouse model of Perry syndrome.Semantic proximity Read ↗

Mouse model of atypical DAT deficiency syndrome uncovers dopamine dysfunction associated with parkinsonism and psychiatric diseaseSemantic proximity Read ↗

A Chinese pedigree with Perry disease caused by the p.Y78H mutation in DCTN1: A 6-year clinical follow-up.Semantic proximity Read ↗

Clinical, pathological and genetic characteristics of Perry disease-new cases and literature review.Semantic proximity Read ↗

Current advances in the clinical management of Perry syndrome: is there hope for the future?Semantic proximity Read ↗

Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease.Semantic proximity Read ↗

Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome.Semantic proximity Read ↗

Characterization of a novel mouse model of Dopamine Transporter Deficiency Syndrome and pharmacological therapeutic strategiesSemantic proximity Read ↗

Phenotype Distinctions in Mice Deficient in the Neuron-Specific α3 Subunit of Na,K-ATPase: Atp1a3tm1Ling/+ and Atp1a3 +/D801Y.Semantic proximity Read ↗

Elucidating the genetics and pathology of Perry syndrome.Semantic proximity Read ↗

DCTN1 mutations in Perry syndrome.Semantic proximity Read ↗

Perry Disease: Concept of a New Disease and Clinical Diagnostic CriteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.