Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential Response to Risperidone in Schizophrenia Patients by KCNH2 Genotype and Drug Metabolizer Status.

The American journal of psychiatry - 1 Jan 2016

Heide Juliane, Zhang Fengyu, Bigos Kristin L, Mann Stefan A, Carr Vaughan J, Shannon Weickert Cynthia, Green Melissa J, Weinberger Daniel R, Vandenberg Jamie I

Abstract excerpt

OBJECTIVE: Antipsychotic drugs target dopamine and serotonin receptors as well as Kv11.1 potassium channels encoded by KCNH2. Variable patient responses and a wide range of side effects, however, limit their efficacy. Slow metabolizer status and gene variants in KCNH2 associated with increased expression of Kv11.1-3.1, an alternatively spliced isoform of Kv11.1, are correlated with improved responses to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Antipsychotic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ERG1 Potassium Channel

Share to Ether-A-Go-Go Potassium Channels

Share to Protein Isoforms

Share to Risperidone

Share to Schizophrenia

Share to Treatment Outcome

Source

Identifiers

PMID: 26481172
DOI: 10.1176/appi.ajp.2015.14050653

Genes

KCNH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential Response to Risperidone in Schizophrenia Patients by KCNH2 Genotype and Drug Metabolizer Status.PMID 26481172Read ↗

Genetic variation in KCNH2 associated with expression in the brain of a unique hERG isoform modulates treatment response in patients with schizophrenia.Semantic proximity Read ↗

Pharmacogenetics analysis of serotonin receptor gene variants and clinical response to risperidone in Han Chinese schizophrenic patients.Semantic proximity Read ↗

SULT4A1 haplotype: conflicting results on its role as a biomarker of antipsychotic response.Semantic proximity Read ↗

A primate-specific, brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia.Semantic proximity Read ↗

Large-scale candidate gene study to identify genetic risk factors predictive of paliperidone treatment response in patients with schizophrenia.Semantic proximity Read ↗

Genome-wide association study of paliperidone efficacy.Semantic proximity Read ↗

Analysis of gene variants previously associated with iloperidone response in patients with schizophrenia who are treated with risperidone.Semantic proximity Read ↗

Genetic determinants of variable metabolism have little impact on the clinical use of leading antipsychotics in the CATIE study.Semantic proximity Read ↗

Iloperidone: A new drug for the treatment of schizophrenia.Semantic proximity Read ↗

Hypothalamic-pituitary-adrenal system, neurotrophic factors and clozapine response: association with FKBP5 and NTRK2 genes.Semantic proximity Read ↗

Analysis of flavin-containing monooxygenase 3 genotype data in populations administered the anti-schizophrenia agent olanzapine.Semantic proximity Read ↗

Functional SNPs in genes encoding the 5-HT2A receptor modify the affinity and potency of several atypical antipsychotic drugs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.