Article
Genome-wide association study of paliperidone efficacy.
Pharmacogenetics and genomics - 1 Jan 2017
Li Qingqin, Wineinger Nathan E, Fu Dong-Jing, Libiger Ondrej, Alphs Larry, Savitz Adam, Gopal Srihari, Cohen Nadine, Schork Nicholas J
Abstract excerpt
OBJECTIVE: Clinical response to the atypical antipsychotic paliperidone is known to vary among schizophrenic patients. We carried out a genome-wide association study to identify common genetic variants predictive of paliperidone efficacy. METHODS: We leveraged a collection of 1390 samples from individuals of European ancestry enrolled in 12 clinical studies investigating the efficacy of the extended-release...
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