Article
Large-scale candidate gene study to identify genetic risk factors predictive of paliperidone treatment response in patients with schizophrenia.
Pharmacogenetics and genomics - 1 Apr 2015
Wang Dai, Fu Dong-Jing, Wu Xiaodong, Shapiro Alice, Favis Reyna, Savitz Adam, Chung Hedy, Alphs Larry, Gopal Srihari, Haas Magali, Cohen Nadine, Li Qingqin
Abstract excerpt
OBJECTIVE: Clinical response to antipsychotic medications can vary markedly in patients with schizophrenia. Identifying genetic variants associated with treatment response could help optimize patient care and outcome. To this end, we carried out a large-scale candidate gene study to identify genetic risk factors predictive of paliperidone efficacy. PATIENTS AND METHODS: A central nervous system custom chip...
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