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Article

Impact of TP53 codon 72 and MDM2 promoter 309 allelic dosage in a Moroccan population with hepatocellular carcinoma.

The International journal of biological markers - 1 Jan 2000

Ezzikouri Sayeh, Essaid El Feydi Abdellah, Afifi Rajae, Benazzouz Mustapha, Hassar Mohammed, Pineau Pascal, Benjelloun Soumaya

Abstract excerpt

Single-nucleotide polymorphisms (SNPs) in codon 72 of the TP53 gene (rs1042522) and in the promoter region of the MDM2 gene (SNP309; rs2279744) have been shown to play a role in the predisposition to many cancers. However, these findings were inconsistent in other tumor types, and ethnicity is suspected to be a critical factor influencing the effects of these SNPs on the cancer risk. The aim of the present study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Hepatocellular
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Share to Gene Dosage
Share to Genes, p53
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Share to Promoter Regions, Genetic
Share to Proto-Oncogene Proteins c-mdm2

Source

Identifiers

PMID: 22180176
DOI: 10.5301/JBM.2011.8881

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Impact of TP53 codon 72 and MDM2 promoter 309 allelic dosage in a Moroccan population with hepatocellular carcinoma.PMID 22180176Read ↗

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