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Article

MDM2 SNP309T>G polymorphism increases susceptibility to hepatitis B virus-related hepatocellular carcinoma in a northeast Han Chinese population.

Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2012

Wang Xi, Zhang Xuelong, Qiu Bing, Tang Yinhua, Sun He, Ji Hongfei, Liu Yan, Shi Lijun, Song Guang, Yang Youlin

Abstract excerpt

BACKGROUND AND AIMS: The murine double minute 2 (MDM2) gene encodes a negative regulator of the tumour protein p53. A single nucleotide polymorphism (SNP) in MDM2 promoter, SNP309 T > G, has been showed to influence MDM2 protein expression and accelerate tumour formation. To investigate further the role of this locus, we examined the association of the SNP with hepatitis B virus (HBV)-related hepatocellular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22413855
DOI: 10.1111/j.1478-3231.2012.02787.x

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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