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Article

Generation of Janus kinase 1 (JAK1) conditional knockout mice.

Genesis (New York, N.Y. : 2000) - 1 Nov 2016

Sakamoto Kazuhito, Wehde Barbara L, Rädler Patrick D, Triplett Aleata A, Wagner Kay-Uwe

Abstract excerpt

The biological functions of the Janus kinase 1 (JAK1) are suggested to be pleiotropic since this signal transducer is ubiquitously expressed and coupled to a variety of cytokine receptors. Consequently, mice that are deficient in this tyrosine kinase were reported to die shortly after birth. To facilitate studies that address the biological and molecular functions of JAK1 during postnatal development, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27671227
DOI: 10.1002/dvg.22982
PMCID: PMC6988131

Genes

JAK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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