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Article

Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie.

PLoS biology - 1 Oct 2015

Parker Joseph, Struhl Gary

Abstract excerpt

Organ growth is controlled by patterning signals that operate locally (e.g., Wingless/Ints [Wnts], Bone Morphogenetic Proteins [BMPs], and Hedgehogs [Hhs]) and scaled by nutrient-dependent signals that act systemically (e.g., Insulin-like peptides [ILPs] transduced by the Target of Rapamycin [TOR] pathway). How cells integrate these distinct inputs to generate organs of the appropriate size and shape is largely...

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Identifiers

PMID: 26474042
DOI: 10.1371/journal.pbio.1002274
PMCID: PMC4608745

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie.PMID 26474042Read ↗

Elucidation of a universal size-control mechanism in Drosophila and mammals.Semantic proximity Read ↗

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP.Semantic proximity Read ↗

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control.Semantic proximity Read ↗

Differential control of Yorkie activity by LKB1/AMPK and the Hippo/Warts cascade in the central nervous system.Semantic proximity Read ↗

The bantam microRNA is a target of the hippo tumor-suppressor pathway.Semantic proximity Read ↗

The Hippo signalling pathway coordinates organ growth and limits developmental variability by controlling dilp8 expression.Semantic proximity Read ↗

The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression.Semantic proximity Read ↗

The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6.Semantic proximity Read ↗

A screen for conditional growth suppressor genes identifies the Drosophila homolog of HD-PTP as a regulator of the oncoprotein Yorkie.Semantic proximity Read ↗

The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts.Semantic proximity Read ↗

Dmp53 activates the Hippo pathway to promote cell death in response to DNA damage.Semantic proximity Read ↗

Control of mitochondrial dynamics by dPGC1 limits Yorkie-induced oncogenic growth in <i>Drosophila</i>Semantic proximity Read ↗

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