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Article

MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism.

BMC cancer - 1 Oct 2008

Paulin Fiona E M, O'Neill Mary, McGregor Gillian, Cassidy Andrew, Ashfield Alison, Ali Clinton W, Munro Alastair J, Baker Lee, Purdie Colin A, Lane David P, Thompson Alastair M

Abstract excerpt

INTRODUCTION: A functional polymorphism within MDM2, SNP309 T>G, has been linked to early onset cancer. This study examined clinical associations of breast cancer with SNP309 in a Scottish Caucasian population and investigated additional MDM2 intron 1 polymorphisms. METHODS: Intron 1 of MDM2 was PCR amplified and directly sequenced from 299 breast cancer patients and 275 cancer free controls and compared with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18828900
DOI: 10.1186/1471-2407-8-281
PMCID: PMC2576335

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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